Theories about the cause of benign prostatic hypertrophy
There are 3 theories put forward about the causes of benign prostatic hypertrophy, are:1. Stem cell theory
In normal circumstances periuretral gland balanced between growth and the dead (SteadyState). New cells are usually grown from stem cells, because of some reason like the factor of age, hormonal disorders or other factors then trigger the stem cells proliferate faster so happens hiperplasi periuretral gland.
2. Theory Reawakening
Re-grow tissues such as stem cell growth during embriologik level, so that periuretral network can grow faster than the surrounding tissue.
3. The theory de Hidrotestoteron
This theory says that hiperplasi caused by the change in the balance between testosterone and estrogen. Testosterone produced by Leydig cells located in the two testes by 90% while 10% in the adrenal gland. However, there were 20% in a state of free testosterone that can cause prostate enlargement. Testosterone that is free to enter into the prostate to penetrate the cell membrane into the cytoplasm of prostate cells to form DHT heseplar acid complex which will affect the RNA that resulted in the synthesis of proteins that can cause cell proliferation.
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